Kodi mukudziwa momwe zida zoyeserazi zimagwira ntchito?

Immunology ndi nkhani yovuta yomwe ili ndi chidziwitso chochuluka. Nkhaniyi ikukudziwitsani pazogulitsa zathu zimagwiritsa ntchito chilankhulo chochepa kwambiri.

Pamunda wopezeka kwambiri, kugwiritsa ntchito kunyumba nthawi zambiri kumagwiritsa ntchito njira yagolide.

Ma nanoparticles agolide amakopeka ndi ma antibodies, ma peptides, kupanga oligonicleotides, ndi mapuloteni ena chifukwa cha kulumikizana kwa sulufhydryl (-po) magulu agolide pamwamba^3-5. A GooMolecle Conjulent aphatikizidwa mwamphamvu mu mapulogalamu odziwika, pomwe mtundu wawo wofiira umagwiritsidwa ntchito poyeserera kunyumba ndi mayeso owoneka ngati nyumba

Chifukwa kugwira ntchito ndi kosavuta, zotsatira zake zimakhala zosavuta kumvetsetsa, zosavuta, mwachangu, zolondola komanso zina. Njira yagolide ya Colloidal ndiye njira yayikulu yodziwira mwachangu pamsika.

Wopikisana ndi sangweji ndi mitundu iwiri ya Colloidal njira ya ogwiritsa ntchito, nthawi zazifupi, zosokoneza pang'ono, zosokoneza pang'ono, komanso kukhala zosavuta kutero. Njirayi imakhazikika pamachitidwe andale za antigen-antibody hybritization. Zogulitsa zathu zimapangidwa ndi magawo anayi: Pad ya zitsanzo, yomwe ndi malo omwe zitsanzo zimaponyedwa; Conjugate pad, pomwe amalemba ma tags ophatikizidwa ndi zinthu zachilengedwe; nembanemba yokhala ndi mzere woyeserera ndi mzere wowongolera kuti agwirizane ndi mgwirizano; ndi kuyamwa pad, yomwe imasungira zinyalala.

1. Mfundo

Ma antibodies awiri omangiriza magetsi omwe ali ndi magetsi omwe amapezeka pa molekyu ya kachilomboka amagwiritsidwa ntchito. Imodzi (yolumikizira antibody) yolembedwa ndi ma nanoparticles agolide ndi ena (antibody (antibody) idakhazikitsidwa pamalo a NC Membrane. Kugwiritsa ntchito mafoloko kumalikonse ku boma la conjugate pad. Ngati njira yoyenera yothetsera vutoli idawonjezedwa patsamba la chimbudzi cha Mzere woyeserera, binder itha kusungunuka nthawi yomweyo pakukhudzana ndi kachilombo kakang'ono kokhala ndi virus. Kenako antibody idapanga zovuta ndi kachilomboka mu gawo lamadzi ndipo limasunthira mosalekeza mpaka atagwidwa ndi antibody okhazikika pamtunda wa NC Membrane, yomwe idapanga chizindikiro chokhudza kachilomboka. Kuphatikiza apo, dokotala wowonjezerapo wina wowonjezera pantibody angagwiritsidwe ntchito kupanga chizindikiro. Pad yomwe ili pamwamba kuti ikhale pamwamba kuti ikhale ndi chipilala chomwe chimapangitsa kuti zovuta zomwe zingapangitse kukhazikika kwa antibody. Mtundu wowoneka wowoneka wochepera mphindi 10, ndipo kulimbikira kumatsimikizira kuchuluka kwa kachilomboka. Mwanjira ina, ma virus omwe analipo mu zitsanzo, gulu lofiira kwambiri limawonekera.

Ndiloleni ndifotokozere mwachidule momwe njira ziwirizi zimagwirira ntchito:

1.Mundleb sandwich njira

Malangizo apawiri a sandwich, makamaka ogwiritsa ntchito mapuloteni akuluakulu a ma protein (anti) .Twa anti amafunikira kuti akwaniritse malo osiyanasiyana a antigen.

2. Njira ya mpikisano

Njira yopikisana nawo imatchula njira yodziwika yomwe antigen adakutidwa ndi chizindikiritso ndi chitetezo cha chizindikiro chagolide cha Antigen. Zotsatira za njirayi zimawerengedwa motere mzere mu mzere wabwino komanso ziwiri zoipa.